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KMID : 0928320150150040168
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Korean Journal of Health Promotion and Disease Prevention
2015 Volume.15 No. 4 p.168 ~ p.174
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Associations between Metabolic Syndrome and Three-dimensional Breast Density Using Digital Mammography
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방선용:Bang Seon-Yong
이효진:Lee Hye-Jin/강지현:Kang Jee-Hyun/유병연:Yu Byung-Yeon
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Abstract
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Background: Metabolic syndrome is associated with increased risk of breast cancer, but little is known about
the association between metabolic syndrome and mammographic density as an independent predictor of
breast cancer. In this study, we investigated the association between metabolic syndrome or its components
and three-dimensional breast density using digital mammography.
Methods: We analyzed cross-sectional data of 166 women, aged 20 or over (61 premenopausal and 105 postmenopausal
women) in a district hospital. Metabolic syndrome was defined according to the modified National
Cholesterol Education Program’s Adult Treatment Panel III (NCEP-ATP III) guideline. We measured volume
percentage of dense breast tissue using digital mammography. Stepwise multiple regression analysis was
used to estimate the association between mammographic density and metabolic syndrome, as well as its
components.
Results: The Mean mammographic density was lower in the group with metabolic syndrome compared with the
group without it. After adjusting for age and menopausal status, multiple regression analysis showed waist circumference
(β＝-3.112, S.E.＝0.927, P＝0.001) and low HDL-cholesterol (β＝-2.967, S.E.＝1.109, P＝0.008)
were independent variables for the percentage of mammographic density, although metabolic syndrome itself
was not. After additional adjustment for body mass index, only low HDL-cholesterol was associated with percentage
of mammographic density (β＝-2.953, S.E.＝0.882, P＝0.001).
Conclusions: In this study, only low HDL cholesterol was associated with three-dimensional mammographic
density independently after adjusting for age, menopausal status and body mass index. These findings need to
be confirmed in further larger prospective studies.
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KEYWORD
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Metabolic syndrome, Mammographic density, High density lipoprotein cholesterol, Breast cancer
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